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J Clin Invest (2021) 131:e145186

PMCID: PMC9827390

The first, and also the rate-limiting step, of melanogenesis for both eumelanin and pheomelanin synthesis is the oxidation of tyrosine to dopaquinone by a copper-containing enzyme called tyrosinase [5]

Collagen-induced vasoconstriction also increased, probably through a decrease in the vasodilator responsiveness to platelet-generated ADP (Lentz, 1997